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Contraindicated (1)pentobarbital will lessen the level or influence of cariprazine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. CYP3A4 is answerable for the development and elimination of cariprazine's Energetic metabolites.pentobarbital will lessen the extent or outcome of eletriptan by impacting hepatic/intestinal en